In October 2000, the UN Security Council unanimously adopted Resolution 1325 on "Women, Peace and Security", calling for women's full and equal participation in all aspects of conflict prevention, resolution and peacebuilding. The world is at last recognizing that gender issues and peace are inextricably connected, and that women's involvement in peace efforts is essential for the prevention of renewed conflict. Given the need for women's involvement in peace and security issues, we must address the reasons why women's influence is (...) limited, why they still do not have access to power or leadership roles, while their level of participation in the armed forces is minimal to non-existent. Meanwhile, wars rage. This paper argues that to think through the deeper connections between gender issues and peace is to engage in an unsettling, necessarily philosophical inquiry about the nature of modern ethical life— as a dysfunctional system of separate and competing ethical imperatives: family and state, public and private, individual and state, masculine and feminine. My inquiry is conducted from the standpoint of Hegel's philosophy. In the Phenomenology of Mind. Hegel draws upon the tragedian Sophocles for his insight that once upon a time in the ancient world, universal ethical substance divided itself into distinct ethical spheres of human and divine law. Human relationships to these ethical worlds were shaped by gender. The division of ethical substance precipitated conflicts that eventually caused the ancient world to collapse. For Hegel, the project of modernity is all about the recovery, in self-conscious form, of a harmonious ethical life, through reconciliation of conflicting ethical worlds. Hegel's philosophy of modern life has its shortfalls, but is a powerful resource for the argument that gender justice is a condition for long-lasting peace. (shrink)

In October 2000, the UN Security Council unanimously adopted Resolution 1325 on "Women, Peace and Security", calling for women's full and equal participation in all aspects of conflict prevention, resolution and peacebuilding. The world is at last recognizing that gender issues and peace are inextricably connected, and that women's involvement in peace efforts is essential for the prevention of renewed conflict. Given the need for women's involvement in peace and security issues, we must address the reasons why women's influence is (...) limited, why they still do not have access to power or leadership roles, while their level of participation in the armed forces is minimal to non-existent. Meanwhile, wars rage. This paper argues that to think through the deeper connections between gender issues and peace is to engage in an unsettling, necessarily philosophical inquiry about the nature of modern ethical life— as a dysfunctional system of separate and competing ethical imperatives: family and state, public and private, individual and state, masculine and feminine. My inquiry is conducted from the standpoint of Hegel's philosophy. In the Phenomenology of Mind. Hegel draws upon the tragedian Sophocles for his insight that once upon a time in the ancient world, universal ethical substance divided itself into distinct ethical spheres of human and divine law. Human relationships to these ethical worlds were shaped by gender. The division of ethical substance precipitated conflicts that eventually caused the ancient world to collapse. For Hegel, the project of modernity is all about the recovery, in self-conscious form, of a harmonious ethical life, through reconciliation of conflicting ethical worlds. Hegel's philosophy of modern life has its shortfalls, but is a powerful resource for the argument that gender justice is a condition for long-lasting peace. (shrink)

One of the most influential analytic philosophers of the late twentieth century, William P. Alston is a leading light in epistemology, philosophy of religion, and the philosophy of language. In this volume, twelve leading philosophers critically discuss the central topics of his work in these areas, including perception, epistemic circularity, justification, the problem of religious diversity, and truth.

_Virtue and Vice, Moral and Epistemic_ presents a series of essays by leading ethicists and epistemologists who offer the latest thinking on the moral and intellectual virtues and vices, the structure of virtue theory, and the connections between virtue and emotion. Cuts across two fields of philosophical inquiry by featuring a dual focus on ethics and epistemology Features cutting-edge work on the moral and intellectual virtues and vices, the structure of virtue theory, and the connections between virtue and emotion Presents (...) a radical new moral theory that makes exemplars the foundation of ethics; and new theories of epistemic vices such as epistemic malevolence and epistemic self-indulgence Represents one of the few collections to address both the moral virtues and the epistemic virtues Explores a new approach in epistemology - virtue epistemology - which emphasizes the importance of intellectual character traits. (shrink)

What is an epistemic virtue? Are epistemic virtues reliable? Are they motivated by a love of truth? Do epistemic virtues produce knowledge and understanding? How can we develop epistemic virtues? The Routledge Handbook of Virtue Epistemology answers all of these questions. This landmark volume provides a pluralistic and comprehensive picture of the field of virtue epistemology. It is the first large-scale volume of its kind on the topic. Composed of 41 chapters, all published here for the first time, it breaks (...) new ground in four areas. It articulates the structure and features of epistemic virtues. It provides in-depth analyses of 10 individual epistemic virtues. It examines the connections between epistemic virtue, knowledge, and understanding. It applies virtue epistemology, and explores its impact on related fields. The contributing authors are pioneers in the study of epistemic virtue. This volume is an outstanding resource for students and scholars in philosophy, as well as researchers in intersecting fields, including education, psychology, political science, and women's studies. (shrink)

One of the most influential analytic philosophers of the late twentieth century, William P. Alston is a leading light in epistemology, philosophy of religion, and the philosophy of language. In this volume, twelve leading philosophers critically discuss the central topics of his work in these areas, including perception, epistemic circularity, justification, the problem of religious diversity, and truth.

One of the most influential analytic philosophers of the late twentieth century, William P. Alston is a leading light in epistemology, philosophy of religion, and the philosophy of language. In this volume, twelve leading philosophers critically discuss the central topics of his work in these areas, including perception, epistemic circularity, justification, the problem of religious diversity, and truth.

This exploratory qualitative study investigated how doctoral students reported their personal and professional interaction experiences that they believed might facilitate or impede their academic pursuits in biomedical research. We collected 19 in-depth interviews with doctoral students in biomedical research from eight universities, and we based our qualitative analytic approach on the work of Miles and Huberman. The results indicated that among different sources and types of interaction, academic and emotional interactions from family and teachers in various stages essentially affected students’ (...) persistence in the biomedical science field. In addition, co-mentorship among peers, departmental environment, and volunteer experiences were other essential factors. This study also found related experiences among women and underrepresented minority students that were important to their academic pursuit. (shrink)

ABSTRACT Digital mental health interventions have emerged as a promising means of expanding access to mental healthcare. Prospective participants reporting severe symptoms or suicidal ideation are often excluded from DMHI trials and may struggle to access alternative treatments. However, evidence suggests that DMHIs are efficacious for people reporting these characteristics. We suggest that there are risks to both including and excluding people from DMHI trials, and we urge researchers to ensure that their eligibility criteria are designed in an evidence-based and (...) ethically conscious manner. We also make specific recommendations for those working in various other capacities within the academic community. (shrink)

Development of the knowledge base for a profession depends on research and scholarship that builds on the insights and work of scholars within the discipline and is disseminated through the literature. The purpose of this study was to examine a unique collection of 79 articles selected by editors as representative of their nursing journals. Articles were assessed for congruence with long‐standing values and conceptual definitions of nursing, and the extent to which they built on prior literature published in nursing. Articles (...) were scored based on whether they reflected four characteristics of nursing as a discipline (holism, social context, goal of health, and consistency with common definitions of nursing); an abstract score on the extent to which the title, abstract, or keywords indicated a general focus on nursing; and a distinction score based on whether the article distinguished nurses or nursing from other providers. Fifty of the articles received an article score of 4, indicating all four disciplinary characteristics were present in the article's content. While the majority of the articles were congruent with fundamental nursing values and perspectives, only 28% of the sources cited were from nursing sources. The lack of citations to nursing literature, coupled with an assessment that reveals gaps in substantive content that builds on nursing knowledge, raises questions about the future of nursing perspectives in the literature. (shrink)

A fundamental question in biology is whether phenotypes can be predicted by ecological or genomic rules. At least five cases of convergent evolution of the crab‐like body plan (with a wide and flattened shape, and a bent abdomen) are known in decapod crustaceans, and have, for over 140 years, been known as “carcinization.” The repeated loss of this body plan has been identified as “decarcinization.” In reviewing the field, we offer phylogenetic strategies to include poorly known groups, and direct evidence (...) from fossils, that will resolve the history of crab evolution and the degree of phenotypic variation within crabs. Proposed ecological advantages of the crab body are summarized into a hypothesis of phenotypic integration suggesting correlated evolution of the carapace shape and abdomen. Our premise provides fertile ground for future studies of the genomic and developmental basis, and the predictability, of the crab‐like body form. (shrink)

A core challenge for contemporary bioethics is how to address the tension between respecting an individual’s autonomy and promoting their wellbeing when these ideals seem to come into conflict (Not...

There is considerable disagreement about the epistemic value of novel predictive success, i.e. when a scientist predicts an unexpected phenomenon, experiments are conducted, and the prediction proves to be accurate. We survey the field on this question, noting both fully articulated views such as weak and strong predictivism, and more nascent views, such as pluralist reasons for the instrumental value of prediction. By examining the various reasons offered for the value of prediction across a range of inferential contexts , we (...) can see that neither weak nor strong predictivism captures all of the reasons for valuing prediction available. A third path is presented, Pluralist Instrumental Predictivism; PIP for short. (shrink)

ABSTRACT:This essay attempts to provide a useful research agenda for researchers in both strategic managementandbusiness ethics. We motivate this agenda by suggesting that the two fields started with similar interests, diverged, and are beginning to converge again. We then identify several streams that hold particular promise for developing our understanding of the relationship between strategy and ethics: stakeholder theory, managerial discretion, behavioral strategy, strategy as practice, and environmental sustainability.

Previous research has demonstrated that hormones, relationship goals, and social context influence interest in the opposite sex. It has not been previously reported, however, whether having a current sexual partner also influences interest in members of the opposite sex. To test this, we obtained explicit and implicit measures of interest by measuring men’s and women’s subjective ratings and response times while they evaluated photos of opposite-sex faces. Fifty-nine men and 56 women rated 510 photos of opposite-sex faces for realism, masculinity, (...) attractiveness, or affect. We found that these subjective ratings were not influenced by partner status in either men or women. However, women who did not report having a current sexual partner spent more time evaluating the photos than women who did have partners, demonstrating greater interest in the photos. Sexual partner status did not predict men’s response times. These findings may reveal that relationship commitment in women suppresses interest in alternative partners. (shrink)

Reingold, Reichle, Glaholt, and Sheridan reported a gaze-contingent eye-movement experiment in which survival-curve analyses were used to examine the effects of word frequency, the availability of parafoveal preview, and initial fixation location on the time course of lexical processing. The key results of these analyses suggest that lexical processing begins very rapidly and is supported by substantial parafoveal processing. Because it is not immediately obvious that these results are congruent with the theoretical assumption that words are processed and identified in (...) a strictly serial manner, we attempted to simulate the experiment using the E-Z Reader model of eye-movement control. These simulations were largely consistent with the empirical results, suggesting that parafoveal processing does play an important functional role by allowing lexical processing to occur rapidly enough to mediate direct control over when the eyes move during reading. (shrink)

Tomasello argues that humans’ sense of moral obligation emerges early in development, relies on a shared “we,” and serves as the foundation of cooperation. This perspective complements our theoretical view of the human self as information agent. The shared “we” promotes not only proximal cooperative goals but also distal ones via the construction of shared understanding – it promotes culture.

The American Journal of Bioethics, Volume 12, Issue 1, Page 16-18, January 2012.

Genomic research projects that collect tissues from deceased organ and tissue donors must obtain the authorization of family decision makers under difficult circumstances that may affect the authorization process. Using a quasi-experimental design, the Ethical, Legal, and Social Issues (ELSI) substudy of the Genotype-Tissue Expression (GTEx) project compared the recall and understanding of the donation authorization process of two groups: family members who had authorized donation of tissues to the GTEx project (the comparison group) and family members who had authorized (...) organ and tissue donations in years previous, who subsequently participated in two different mock-authorization processes that mimicked the GTEx authorization process (the intervention groups). Participants in the comparison and intervention groups were matched on key demographic characteristics.We found that participants in the intervention groups who experienced a mock-authorization process demonstrated better recall of the tissue donation request than members of the comparison group. Our data indicate that the stress associated with the loss of a loved one limited the ability of family members to recall details about the GTEx project. However, we found a similar lack of knowledge in both the comparison and the intervention group participants, suggesting lack of knowledge may be due to the complexity and unfamiliarity of the information presented to them during the authorization process. We discuss these findings in the context of everyday clinical decision making in cognitively challenging conditions. (shrink)

Hollywood films partially construct how Americans think about education. Recent work on the representation of schools in American cinema has highlighted the role of class difference in shaping school film genres. It has also advanced the idea that a nuanced understanding of American individualism helps to explain why the different class genres are shaped as they are. This article attempts to refine this theoretical approach by focusing on the paradox of individualism, which suggests that individualism must always be dependent on (...) community. We examine 5 films (Rushmore 1988, The Breakfast Club 1985, Mona Lisa Smile 2003, School of Rock 2003, and Stand and Deliver 1988) and argue that, although the values of individualism are certainly celebrated, these films also show, perhaps unwittingly, that the achievements of individualism require robust student communities. We describe how student communities function in these films, what achievements they make possible, and what obstacles they face. (shrink)

Preadolescence is an important period for the consolidation of certain arithmetic facts, and the development of problem-solving strategies. Obese subjects seem to have poorer academic performance in math than their normal-weight peers, suggesting a negative effect of obesity on math skills in critical developmental periods. To test this hypothesis, event-related potentials were collected during a delayed-verification math task using simple addition and subtraction problems in obese [above 95th body mass index percentile] and non-obese preteens with different levels of math skill; (...) thirty-one with low math skills and thirty-one with high math skills. No significant differences between weight groups were observed in task accuracy regardless of their mathematical skill level. For ERPs, electrophysiological differences were found only in the subtraction condition; participants with obesity showed an electrophysiologic pattern associated with a reduced ability to allocate attention resources regardless of their math skill level, these differences were characterized by longer P300 latency than their normal-weight peers. Moreover, the participants with obesity with high math skills displayed hypoactivity in left superior parietal lobule compared with their normal-weight peers. Additionally, obese preteens with low math skills displayed smaller arithmetic N400 amplitude than non-obese participants, reflecting difficulties in retrieving visual, semantic, and lexical information about numbers. We conclude that participants with obesity are less able than their normal-weight peers to deploy their attention regardless of their behavioral performance, which seems to have a greater effect on obese participants with low math skills because they also show problems in the retrieval of solutions from working memory, resulting in a delay in the development of mathematical skills. (shrink)

Very few researchers have reported on procedures of recruiting, obtaining informed consent, and compensating participants in health research in the Arabian Gulf Region. Empirical research can inform the debate about whether to adjust these procedures for culturally diverse settings. Our objective was to delineate procedures related to recruiting, obtaining informed consent, and compensating health research participants in the extremely high-density multicultural setting of Qatar.

BackgroundWhen conducting research with Indigenous populations consent should be sought from both individual participants and the local community. We aimed to search and summarise the literature about methods for seeking consent for research with Indigenous populations.MethodsA systematic literature search was conducted for articles that describe or evaluate the process of seeking informed consent for research with Indigenous participants. Guidelines for ethical research and for seeking consent with Indigenous people are also included in our review.ResultsOf 1447 articles found 1391 were excluded (...) ; 56 were relevant and included. Articles were categorised into original research that evaluated the consent process or publications detailing the process of seeking consent and guidelines for ethical research. Guidelines were categorised into international ; national and state/regional/local guidelines. In five studies based in Australia, Canada and The United States of America the consent process with Indigenous people was objectively evaluated. In 13 other studies interpreters, voice recording, videos, pictures, flipcharts and “plain language” forms were used to assist in seeking consent but these processes were not evaluated. Some Indigenous organisations provide examples of community-designed resources for seeking consent and describe methods of community engagement, but none are evaluated. International, national and local ethical guidelines stress the importance of upholding Indigenous values but fail to specify methods for engaging communities or obtaining individual consent. In the ‘Grey literature’ concerns about the consent process are identified but no solutions are offered.ConclusionConsultation with Indigenous communities is needed to determine how consent should be sought from the community and the individual, and how to evaluate this process. (shrink)

This article evaluates Alessandra Tanesini’s analyses of the intellectual virtues and vices of self-assessment, as characterized in her book The Mismeasure of the Self (2021 Tanesini, A. 2021. The Mismeasure of the Self. Oxford: Oxford University Press.[Crossref], [Google Scholar]). Section 1 explains Tanesini’s rich accounts of the virtues of intellectual humility and pride. Contra Tanesini, section 2 suggests an alternative account according to which the intellectual virtues of humility and pride require reliability about one’s limitations and strengths. This is an (...) externalist version of the limitations-owning analysis, which takes the virtues of intellectual humility and pride to consist in (roughly): dispositions to appropriately attend to and own one’s limitations and strengths (Whitcomb et al. 2017 Whitcomb, D., H. Battaly, J. Baehr, and D. Howard-Snyder. 2017. “Intellectual Humility: Owning Our Limitations.” Philosophy and Phenomenological Research 94 (3): 509–539. doi:10.1111/phpr.12228.[Crossref], [Web of Science ®], [Google Scholar]). I also explore whether the intellectual vices of self-assessment require unreliability about one’s limitations and strengths. In so doing, I raise a question about Tanesini’s analysis of self-abasement. (shrink)

The consent and community engagement process for research with Indigenous communities is rarely evaluated. Research protocols are not always collaborative, inclusive or culturally respectful. If participants do not trust or understand the research, selection bias may occur in recruitment, affecting study results potentially denying participants the opportunity to provide more knowledge and greater understanding about their community. Poorly informed consent can also harm the individual participant and the community as a whole. Invited by local Aboriginal community leaders of the Fitzroy (...) Valley, the Kimberley, Western Australia, The Picture Talk project explores the consent process for research. Focus groups of Aboriginal community members were conducted to establish preferences for methods of seeking individual consent. Transcripts were analysed through NVivo10 Qualitative software using grounded theory with inductive and deductive coding. Themes were synthesised with quotes highlighted. Focus groups with Aboriginal community members were facilitated by a Community Navigator as a cultural guide and interpreter and a researcher. Participants were recruited from all main language groups of the Fitzroy Valley – Gooniyandi, Walmajarri, Wangkatjungka, Bunuba and Nikinya. Participants were aged ≥18 years, with 5 female groups and one male group. Themes identified include: Reputation and trust is essential; The Community Navigator is key; Pictures give the words meaning – milli milli versus Pictures; Achieving consensus in circles; Signing for consent; and Research is needed in the Valley. Aboriginal communities of the Fitzroy Valley recommend that researchers collaborate with local leaders, develop trust and foster a good reputation in the community prior to research. Local Aboriginal researchers should be employed to provide cultural guidance throughout the research process and interpret local languages especially for elders. Pictures are preferred to written text to explain research information and most prefer to sign for consent. The Fitzroy Valley welcomes research when collaborative and for the benefit of the community. Future research could include exploring how to support young people, promote health screening and improve understanding of medical knowledge. (shrink)

Drawing on philosophical thought from the eighteenth century as well as conceptual frameworks developed in the twenty-first century, the essays in Beyond Sense and Sensibility examine moral formation as represented in or implicitly produced by literary works of late eighteenth-century British authors.

In lieu of an abstract, here is a brief excerpt of the content:Feminist Studies 46, no. 2. © 2020 by Feminist Studies, Inc. 259 Heather Berg Left of #MeToo In her 1949 call to “End the Neglect of the Problems of the Negro Woman!” Claudia Jones tells the story of Dora Jones, a Black domestic worker enslaved for forty years by her employer.1 Elizabeth Ingalls, a wealthy white woman, had traveled to Dora Jones’s Alabama home as a missionary teacher (...) and persuaded the seventeen-year-old Jones to travel to Boston as her housekeeper in 1907. Ingalls would keep Jones captive until 1947. In the intervening years, Ingalls subjected Jones to routine physical abuse and an endless expanse of intensive, unpaid domestic labor. With no days off and permitted to leave only for errands, Jones was allowed no personal relationships or contact with the outside world. Ingalls’s first husband, the bureaucrat Walter Harman, raped Jones over the course of three years, and Jones became pregnant.2 Ingalls would term this an “affair” and, as court documents showed, pushed Jones to “submit” to an abortion.3 Later, when Jones protested her abusive conditions and attempted to escape, Ingalls blackmailed her, threatening 1. Claudia Jones, “An End to the Neglect of the Problems of the Negro Woman!” Political Affairs (June 1949): 11. 2. I am inferring non-consent based on Jones’s captivity. On unfreedom and the politics of consent, see Saidiya Hartman, “Seduction and the Ruses of Power,” Callaloo 19, no. 2 (1996): 537–60. 3. United States v. Ingalls et al., Cr. No. 10568-SD (District Court, S.D. California, July 29, 1947). 260 Heather Berg to “commit Jones to prison” for interracial “adultery” and the abortion she had as a result. Jones finally won her freedom in 1947, a year after Ingalls’s adult daughter reported her mother to the police.4 Claudia Jones offers Dora Jones’s story as evidence of the exceptional precarity of Black women domestic workers. Like others in her cohort of “black left feminists” (to borrow Erik McDuffie’s term), Jones focused on domestic work as a field that epitomized the “triple oppression” at which she took aim.5 Sexual violence at work is not exceptional in Claudia Jones’s telling. Instead, it operates alongside a catalog of abuses at the intersection of capitalism, state terror, the degradation of women, imperialism, and white supremacy. An active member of the Communist Party, Jones insisted on thinking these systems together, maintaining that only through collective struggle against them could justice be won. Women would not be comrades in that struggle in any simple way. Jones was sharply critical of the idea that Black women’s oppression could be explained by “the rotten bourgeois notion about a ‘battle of the sexes.’”6 Instead, she urged working-class Black people to fight “against their common oppressors, the white ruling class.”7 Solidarity among women was illusory, in part, because of white women’s roles as employers of Black women’s domestic work. Against a narrative of sexual violence that describes simple dominance by men over women, Dora Jones’s story highlights the ways that systems of domination work together to enable abuse. Her suffering was not the same as that visited on bourgeois white women. Instead, it was perpetrated and enabled by one. There is no sisterhood to be found here. A critique of this framework is now common sense in most feminist circles, and yet the loudest feminist intervention in recent years trades in exactly the “bourgeois notion about a ‘battle of the sexes.’” Some seventy years after “An End to the Neglect’s” publication, the #MeToo movement has brought broad international attention to 4. For an overview of the case and its legal legacy, see Risa L. Goluboff, The Lost Promise of Civil Rights (Cambridge, MA: Harvard University Press, 2010), 162–5. 5. Erik S. McDuffie, Sojourning for Freedom: Black Women, American Communism, and the Making of Black Left Feminism (Durham, NC: Duke University Press, 2011), 9. 6. Jones, “An End to the Neglect of the Problems of the Negro Woman!” 13. 7. Ibid. Heather Berg 261 the problem of workplace sexual violence. In 2006, civil rights activist Tarana Burke founded an anti-violence movement based... (shrink)

This article considers a strange, understudied work of eighteenth-century musical theatre, Thomas D’Urfey’s Wonders in the Sun (1706). This highly intertextual, generically heterogeneous comic opera is a pastiche of literary and performative modes and ultimately a machine for generating wonder; it draws on elements from Aristophanes’ The Birds, seventeenth-century masque and semi-opera, as well as the lunar fictions. The article situates this play not only within a history of literary wonder and stage spectacle, but within the English tradition of politicized (...) animal fable. Discussing D’Urfey’s comic opera against selections from John Gay’s Fables, it argues that the utopian/dystopian animal in these imaginative satires reveals the period’s twinned fascinations with discovery and alterity, as well as emergent discomfiture with anthro- and Eurocentric Enlightenment beliefs. (shrink)

This article considers a strange, understudied work of eighteenth-century musical theatre, Thomas D’Urfey’s Wonders in the Sun (1706). This highly intertextual, generically heterogeneous comic opera is a pastiche of literary and performative modes and ultimately a machine for generating wonder; it draws on elements from Aristophanes’ The Birds, seventeenth-century masque and semi-opera, as well as the lunar fictions. The article situates this play not only within a history of literary wonder and stage spectacle, but within the English tradition of politicized (...) animal fable. Discussing D’Urfey’s comic opera against selections from John Gay’s Fables, it argues that the utopian/dystopian animal in these imaginative satires reveals the period’s twinned fascinations with discovery and alterity, as well as emergent discomfiture with anthro- and Eurocentric Enlightenment beliefs. (shrink)

Acute exercise consistently benefits both emotion and cognition, particularly cognitive control. We evaluated acute endurance exercise influences on emotion, domain-general cognitive control, and the cognitive control of emotion, specifically cognitive reappraisal. Thirty-six endurance runners, defined as running at least 30 miles per week with one weekly run of at least 9 miles (21 female, age 18-30 years) participated. In a repeated measures design, participants walked at 57% age-adjusted maximum heart rate (HRmax) (range 51-63%) and ran at 70% HRmax (range 64-76%) (...) for 90 minutes on two separate days. Participants completed measures of emotional state and the Stroop test of domain-general cognitive control before, every 30 minutes during, and 30 minutes after exercise. Participants also completed a cognitive reappraisal task after exercise. Functional near-infrared spectroscopy tracked changes in oxygenated and deoxygenated hemoglobin levels in the prefrontal cortex (PFC). Endurance exercise elevated positive emotion and cognitive reappraisal success. Endurance exercise reduced Stroop response time and test-evoked PFC oxygenation during exercise. Results suggest that even at relatively moderate intensities, endurance athletes benefit emotionally from running both during and after exercise, and task-related prefrontal cortex oxygenation reductions do not appear to hinder prefrontal-dependent cognitive control. (shrink)

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

Contrary to concerns of some critics, we present evidence that biomedical research is not dominated by a small handful of model organisms. An exhaustive analysis of research literature suggests that the diversity of experimental organisms in biomedical research has increased substantially since 1975. There has been a longstanding worry that organism‐centric funding policies can lead to biases in experimental organism choice, and thus negatively impact the direction of research and the interpretation of results. Critics have argued that a focus on (...) model organisms has unduly constrained the diversity of experimental organisms. The availability of large electronic databases of scientific literature, combined with interest in quantitative methods among philosophers of science, presents new opportunities for data‐driven investigations into organism choice in biomedical research. The diversity of organisms used in NIH‐funded research may be considerably lower than in the broader biomedical sciences, and may be subject to greater constraints on organism choice. (shrink)

Introduction to Philosophy: Philosophy of Mind surveys the central themes in philosophy of mind and places them in a historical and contemporary context intended to engage first-time readers in the field. It focuses on debates about the status and character of the mind and its seemingly subjective nature in an apparently more objective world. The book is designed to be used alone or alongside a reader of historical and contemporary original sources, and is freely available in web and digital formats (...) at https: //press.rebus.community/intro-to-phil-of-mind/ If you are adopting or adapting this book for a course, please let us know on our adoption form for the Introduction to Philosophy open textbook series: https: //docs.google.com/forms/d/e/1FAIpQLSdwf2E7bRGvWefjhNZ07kgpgnNFxVxxp-iidPE5gfDBQNGBGg/viewform?usp=sf _link. Cover art by Heather Salazer; cover design by Jonathan Lashley. One of nine books in the Introduction to Philosophy open textbook series. (shrink)